主要原著論文

主要原著論文

  • Tsubota K, Nakamori K. Dry eyes and video display terminals. N Engl J Med. 1993 Feb 25;328(8):584.
  • Tsubota K, Toda I, Saito H, Shinozaki N, Shimazaki J. Reconstruction of the Corneal Epithelium by Limbal Allograft Transplantation for Severe Ocular Surface Disorders. Ophthalmology. 1995;102:1486-1496.
  • Tsubota K, Toda I, Nakamori K. Poor illumination, VDTs, and desiccated eyes. Lancet. 1996 Mar 16;347(9003):768-9.
  • Tsubota K, Satake Y, Shimazaki J. Treatment of severe dry eye. Lancet. 1996 Jul 13;348(9020):123.
  • Tsubota K, Satake Y, Ohyama M, Toda I, Takano Y, Ono M, Shinozaki N, Shimazaki J. Surgical reconstruction of the ocular surface in advanced ocular cicatricial pemphigoid and Stevens-Johnson syndrome. Am J Ophthalmol. 1996;122:38-52.
  • Tsubota K. Corneal epithelial stem-cell transplantation. Lancet. 1997 May 24;349(9064):1556.
  • Tsubota K, Saito I, Ishimaru N, Hayashi Y. Use of topical cyclosporin a in a primary Sjogren's syndrome mouse model. Invest Ophthalmol Vis Sci. 1998;39:1551-1559.
  • Tsubota K, Satake Y, Kaido M, Shinozaki N, Shimmura S, Bissen-Miyajima H, Shimazaki J. Treatment of severe ocular-surface disorders with corneal epithelial stem-cell transplantation. N Engl J Med. 1999;340:1697-1703.
  • Shimazaki J, Kaido M, Shinozaki N, Shimmura S, Munkhbat B, Hagihara M, Tsuji K, Tsubota K. Evidence of long-term survival of donor-derived cells after limbal allograft transplantation. Invest Ophthalmol Vis Sci. 1999;40:1664-1668.
  • Tsubota K, Fujita H, Tsuzaka K, Takeuchi T. Mikulicz's disease and Sjogren's syndrome. Invest Ophthalmol Vis Sci. 2000;41:1666-1673.
  • Tsubota K, Hirai S, King LS, Agre P, Ishida N. Defective cellular trafficking of lacrimal gland aquaporin-5 in Sjogren's syndrome. Lancet. 2001;357:688-689.
  • Yoshida S, Shimmura S, Nagoshi N, Fukuda K, Matsuzaki Y, Okano H, Tsubota K. Isolation of multipotent neural crest-derived stem cells from the adult mouse cornea. Stem Cells. 2006 Dec;24(12):2714-22.
  • Imamura Y, Noda S, Hashizume K, Shinoda K, Yamaguchi M, Uchiyama S, Shimizu T, Mizushima Y, Shirasawa T, Tsubota K. Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: a model of age-related macular degeneration.　Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11282-7.
  • Uchino M, Schaumberg DA, Dogru M, Uchino Y, Fukagawa K, Shimmura S, Satoh T, Takebayashi T, Tsubota K. Prevalence of dry eye disease among Japanese visual display terminal users. Ophthalmology. 2008 Nov;115(11):1982-8.
  • Nakamura S, Kinoshita S, Yokoi N, Ogawa Y, Shibuya M, Nakashima H, Hisamura R, Imada T, Imagawa T, Uehara M, Shibuya I, Dogru M, Ward S, Tsubota K. Lacrimal hypofunction as a new mechanism of dry eye in visual display terminal users. PLoS ONE 2010;5(6): e11119.
  • Uchino M, Nishiwaki Y, Michikawa T, Shirakawa K, Kuwahara E, Yamada M, Dogru M, Schaumberg DA, Kawakita T, Takebayashi T, Tsubota K. Prevalence and risk factors of dry eye disease in Japan: Koumi study. Ophthalmology. 2011 Dec;118(12):2361-7.
  • Hirayama M, Ogawa M, Oshima M, Sekine Y, Ishida K, Yamashita K, Ikeda K, Shimmura S, Kawakita T, Tsubota K, Tsuji T. Functional lacrimal gland regeneration by transplantation of a bioengineered organ germ. Nat Commun. 2013;4:2497.
  • Kawashima M, Uchino M, Yokoi N, Uchino Y, Dogru M, Komuro A, Sonomura Y, Kato H, Kinoshita S, Mimura M, Tsubota K. Associations between subjective happiness and dry eye disease: a new perspective from the Osaka study. PLoS One. 2015 Apr 1;10(4):e0123299.
  • Ayaki M, Nagura T, Toyama Y, Negishi K, Tsubota K. Motor function benefits of visual restoration measured in age-related cataract and simulated patients: Case-control and clinical experimental studies. Sci Rep. 2015 Sep 30;5:14595.
  • Ayaki M, Kawashima M, Negishi K, Kishimoto T, Mimura M, Tsubota K. Sleep and mood disorders in dry eye disease and allied irritating ocular diseases. Sci Rep. 2016 Mar 1;6:22480.